DSpace Collection: http://dspace.bsuedu.ru/handle/123456789/64325 2026-04-05T21:41:30Z Effect of some compounds from the series of derivatives of cyanothioacetamide with analgesic activity on liver function parameters of rats with chronic administration of paracetamol against the background of alcohol load http://dspace.bsuedu.ru/handle/123456789/65294 Title: Effect of some compounds from the series of derivatives of cyanothioacetamide with analgesic activity on liver function parameters of rats with chronic administration of paracetamol against the background of alcohol load Authors: Bibik, E.Yu.; Bukhtoyarova, D.R.; Krivokolysko, S.G. Abstract: Derivatives of 1,4-dihydropyridines from a series of α-cyanothioacetamide derivatives are a potentially promising class of compounds with analgesic activity. The most pronounced hepatoprotective properties were shown by the compound with the code d02-123 2025-01-01T00:00:00Z Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S) http://dspace.bsuedu.ru/handle/123456789/65291 Title: Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S) Authors: Shmigerova, V.S.; Stepenko, Yu.V.; Kurbatova, A.A.; Zhunusov, N.S.; Lyapkalov, N.S. Abstract: Neurodegenerative diseases affecting neurons represent a wide spectrum of pathological conditions. To slow the accumulation of pathological tau protein, therapeutic interventions such as a pharmaceutical composition consisting of the tetrapeptide HAEЕ, zinc, and albumin may be employed. The pharmaceutical composition HAEE-Zn-HSA at a dosage of 75 mg/kg, using a model of homozygous mice from a transgenic line with overexpression of human mutant tau protein P301S, demonstrated high levels of adaptive and exploratory activity and improved motor function 2025-01-01T00:00:00Z The enriched cross-maze test as a model of impulsivity and attention deficit in spontaneously hypertensive rats http://dspace.bsuedu.ru/handle/123456789/65290 Title: The enriched cross-maze test as a model of impulsivity and attention deficit in spontaneously hypertensive rats Authors: Salimov, R.M.; Kovalev, G.I. Abstract: Results of the present paper demonstrate heterogeneity among the SH rats line regarding measures of impulsivity and attention deficit obtained by the use of the enriched cross-maze test and assesses the effects of clinically effective anti-ADHD drug atomoxetine 2025-01-01T00:00:00Z Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms http://dspace.bsuedu.ru/handle/123456789/65288 Title: Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms Authors: Pyurveev, S.S.; Lebedev, A.A.; Bychkov, E.R.; Shabanov, P.D. Abstract: This study explores the effects of kisspeptin-10 on impulsivity, compulsivity, and reinforcement mechanisms. Kisspeptin-10 dose 1 mg/kg significantly modulates impulsive and compulsive behaviors, as well as reinforcing mechanisms, highlighting its potential as a therapeutic target for conditions characterized by dysregulated decision-making and compulsivity 2025-01-01T00:00:00Z