http://dspace.bsuedu.ru/handle/123456789/64324 Sun, 05 Apr 2026 17:55:56 GMT 2026-04-05T17:55:56Z http://dspace.bsuedu.ru/handle/123456789/66373 Title: Investigation of imidazole-4,5-dicarboxylic acid derivatives activity on visceral pain in mice Authors: Yakovleva, E. E.; Kamalova, M. T.; Yakovleva, V. G.; Brusina, M. A.; Bychkov, E. R. Abstract: Experimental studies on rodents have shown that mGluR1 receptor inhibitors demonstrate antinociceptive potential in acute pain models. New ligands of the glutamate NMDA-receptor complex are imidazole-4,5-dicarboxylic acid derivatives, which conformational rigidity allows increasing selectivity interaction and decreasing a number of side effects with the implementiation a high analgesic potential Wed, 01 Jan 2025 00:00:00 GMT http://dspace.bsuedu.ru/handle/123456789/66373 2025-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/66372 Title: Semaglutide reduces hypothalamic glial cell damage in a streptozocin-induced model of Alzheimer's disease Authors: Voronkov, D. N.; Stavrovskaya, A. V.; Pavlova, A. K.; Potapov, I. A.; Olshansky, A. S. Abstract: Reactive changes in glial cells, as well as their dysfunction, particularly cerebrospinal fluid dynamics disturbances, are associated with multiple neurodegenerative diseases and Alzheimer’s disease (AD). Intraventricular administration of streptozotocin (STZ) is considered a model of sporadic AD, though data on hypothalamic glial cell changes, ependymal glia, and tanycytes in this model remain limited Wed, 01 Jan 2025 00:00:00 GMT http://dspace.bsuedu.ru/handle/123456789/66372 2025-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/66371 Title: Current concepts of pathogenesis of depressive disorder: A literature review Authors: Spasov, A. A.; Maltsev, D. V.; Maltseva, M. O. Abstract: Despite the high prevalence of depressive disorders, the pathogenesis of depression has not been fully established. Recently, a significant number of works have been published demonstrating mechanisms of development of this pathology that differ from classic monoaminergic theory. In-depth study of such mechanisms can be used as new approaches to the design of more advanced antidepressant drugs Wed, 01 Jan 2025 00:00:00 GMT http://dspace.bsuedu.ru/handle/123456789/66371 2025-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/66370 Title: Glucose effects on the brain in the healthy and unhealthy individuals: metabolic and cognitive aspects Authors: Ragimova, A. A.; Petelin, D. S.; Volel, B. A.; Zinchenko, O. O. Abstract: Glucose serves as the brain’s primary energy substrate and plays a critical role in maintaining cognitive function. Even slight fluctuations in glucose levels can influence attention, learning, and emotional regulation Wed, 01 Jan 2025 00:00:00 GMT http://dspace.bsuedu.ru/handle/123456789/66370 2025-01-01T00:00:00Z