http://dspace.bsu.edu.ru/handle/123456789/25526| Title: | A novel polymorphism in the promoter of the CYP4A11 gene is associated with susceptibility to coronary artery disease |
| Authors: | Sirotina, S. Ponomarenko, I. Kharchenko, A. Bykanova, M. Churnosov, M. |
| Keywords: | medicine cardiology internal medicine coronary artery disease cardiovascular disorder nucleotide polymorphisms |
| Issue Date: | 2018 |
| Citation: | A novel polymorphism in the promoter of the CYP4A11 gene is associated with susceptibility to coronary artery disease / S. Sirotina [et al.] // Disease Markers : electronic journal. - 2018. - Vol.2018. - Art. ID 5812802. |
| Abstract: | Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population. In silico analysis allowed identifying that SNP rs9332978 is located at a binding site for multiple transcription factors; many of them are known to regulate the pathways involved in the pathogenesis of CAD |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/25526 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Sirotina_A_Novel_18.pdf | 904.82 kB | Adobe PDF | View/Open |
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