Pharmacotherapeutic strategies for endothelial dysfunction correction with use of statines in syndrome of systemic inflammatory response

Abstract

The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins‘ new pharmacological effects and its combination with endothelioprotectors in the SIRS correction. Materals and Methods: In experiments on mice, rats and rabbits, the antiinflammatory, cardioprotective and endothelioprotective effects of statins and endothelioprotectors were explored.