Antitumor efficiency of the natural alkaloid berberine complexed with C₆₀ fullerene in Lewis lung carcinoma in vitro and in vivo

Abstract

Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choosing the right dose, there is a need to improve approaches of Ber use in anticancer therapy. In this study, Ber, noncovalently bound to a carbon nanostructure C₆₀ fullerene at various molar ratios of the components, was explored against Lewis lung carcinoma