http://dspace.bsu.edu.ru/handle/123456789/52727| Title: | Pharmacological correction of the sequelae of acute alcohol-induced myocardial damage with new derivatives of neuroactive amino acids coupled with the blockade of the neuronal NO synthase isoform |
| Authors: | Kustova, M. V. Perfilova, V. N. Prokofiev, I. I. Musyko, E. A. Kucheryavenko, A. S. |
| Keywords: | medicine pharmacology acute alcohol intoxication cardioprotection derivatives of GABA and glutamic acid, neuronal NOS |
| Issue Date: | 2022 |
| Citation: | Pharmacological correction of the sequelae of acute alcohol-induced myocardial damage with new derivatives of neuroactive amino acids coupled with the blockade of the neuronal NO synthase isoform / M.V. Kustova [et al.] // Research Results in Pharmacology. - 2022. - Vol.8, №4.-P. 1-13. - Doi: 10.3897/rrpharmacology.8.90241. - Refer.: p. 11-13. |
| Abstract: | Acute alcohol intoxication (AAI) induces a number of myocardial disorders, which result in mitochondrial dysfunction in cardiomyocytes, oxidative stress, and decreased cardiac contractility. Nitric oxide produced by the nNOS is one of the major modulators of cardiac activity. New derivatives of GABA (RSPU-260 compound) and glutamate (glufimet) can be potentially regarded as such agents as the interaction between the NO system and the GABA and glutamatergic systems has been proved |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/52727 |
| Appears in Collections: | Vol. 8, № 4 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kustova_Pharmacological.pdf | 843.74 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.