http://dspace.bsu.edu.ru/handle/123456789/52123| Title: | A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice |
| Authors: | Chaprov, K. Rezvykh, A. Funikov, S. Ivanova, T. A. Deykin, A. V. |
| Keywords: | medicine medical genetics ALS mouse model drug effects FUS gamma-carbolines motor neuron disease TLS |
| Issue Date: | 2021 |
| Citation: | A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice / K. Chaprov [et al.] // CNS Neuroscience & Therapeutics. - 2021. - Vol.27, №7.-P. 765-775. |
| Abstract: | Avtors developed a CatWalk analysis protocol that allows detection of gait changes in FUS transgenic mice and the effect of DF402 on their gait already at early pre-symptomatic stage. At this stage, a limited number of genes significantly change expression in transgenic mice and for 60% of these genes, DF402 treatment causes the reversion of the expression pattern |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/52123 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Deykin_A bioisostere_21.pdf | 544.15 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.