In silico exploring the mechanisms of action of diterpenoids from Rabdosia serra against lung cancer through inhibition of the anti-apoptotic pathway

Abstract

Apoptosis resistance in non-small cell lung cancer is frequently sustained by pro-survival Bcl-2 family proteins such as Mcl-1, motivating the search for new Mcl-1 inhibitors from natural products, including diterpenoids from Rabdosia serra