Designing siRNA nanocarriers for myocardial ischemia/reperfusion injury: pathobiological targets, delivery barriers, platform strategies, and translational constraints

Abstract

The central message of this review is that carrier design should begin with the delivery barrier, not with the material category - and that for the heart, the barrier chain includes microvascular obstruction and endothelial permeability as an independent access step that platform-organized reviews have not yet treated as a design variable